Rifampin drug interaction as cause of intractable acute postoperative pain

Prosthetic joint replacement is one of the most valuable medical progresses of recent decades and it’s projected to increase by 673% in the United States alone by 2030 [1]. However, prosthetic joint infection is a serious complication of arthroplasty that is associated with significant mortality, morbidity and costs [2]. Although prosthetic joint infection occurs in a relatively small proportion of patients (1-3%), it is a destructive complication and the number of this infection is expected to rise in the years to come [3-6]. Rifampin is broad spectrum antibacterial that is commonly used in patients with prosthetic joint infections [7]. This medication is a potent cytochrome P450 inducer which increases the rate of metabolism of many other drugs [8].